Most relevant publications of Team Leaders

Tristan Bereau
- Bereau T & Kremer K (2015) Automated parametrization of the coarse-grained Martini force field for small organic molecules, JCTC 11:2783.
- Bereau T & Kremer K (2016) Protein-backbone thermodynamics across the membrane interface, JPCB 120:6391-6400.

Helge Bode
- Lorenzen W et al. (2014) A multifunctional enzyme is involved in bacterial ether lipid biosynthesis, Nat. Chem. Biol. 10: 425-427.
- Bode HB et al. (2015) Structure Elucidation and Activity of Kolossin A, the D-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase. Angew. Chem. Int. Ed. 54: 10352-10355.

Ivan Dikic
- Fiskin E et al. (2016) Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol Cell. 62:967-81.
- Khaminets A et al. (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522:354-8.

Achilleas Frangakis
- Grahammer F et al. (2016) A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. pii: e86177.
- Eltsov M et al. (2015) Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography. Nature Cell.

Simone Fulda
- Safferthal C, Rohde K & Fulda S (2017) Therapeutic targeting of necroptosis by Smac  mimetic bypasses apoptosis resistance in acute myeloid leukemia cells. Oncogene 36,1487-1502.
- Rohde K, Kleinesudeik L, Roesler S, Loewe O, Heidler J, Schroeder K, Wittig I, Droese S & Fulda S (2017) A Bakdependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ. 24, 83-97.
- Belz K, Schoeneberger H, Wehner S, Weigert A, Bönig H, Klingebiel T, Fichtner I & Fulda S (2014) Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. Blood 124, 240-50.
- Loeder S, Fakler M, Schoeneberger H, Cristofanon S, Leibacher J, Vanlangenakker N, Bertrand MJM, Vandenabeele P, Jeremias I, Debatin KM, Fulda S (2012) RIP is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Leukemia, 26, 1020-9.
- Fulda S & Vucic D (2012) Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov, 11, 109-24.

Martin Grininger
- Gajewski J, Pavlovic RR, Fischer MM, Boles E & Grininger M (2017) Engineering fungal de novo fatty acid synthesis for short chain fatty acid production. Nat Commun, 8, 14650.
- Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H & Grininger M (2017) Engineering fatty acid synthases for directed polyketide production. Nat Chem Biol, 13, 363-365.
- Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK & Nielsen J (2017) Expanding the product portfolio of fungal type I fatty acid synthases. Nat Chem Biol, 13, 360-362.
- Fischer M et al. (2015) Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS. Protein Sci. 24:987-95.
- Ciccarelli L et al. (2013) Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex. Structure. 21:1251-7.

Mike Heilemann
- Krüger CL, Zeuner M-T, Cottrell G S, Widera M & Heilemann M (2017) Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization. Science Signaling 10, 503, eaan1308.
- Harwardt M-LIE, Young P, Bleymüller WM, Meyer T, Karathanasis C, Niemann HH, Heilemann M & Dietz MS (2017) Membrane dynamics of resting and InlB-activated MET receptor tyrosine kinase studied by single-molecule tracking. FEBS Open Bio 7(9), 1422-1440.
- van Wijk SJL, Fricke F, Herhaus L, Hötte K, Pampaloni F, Fulda S, Heilemann, M & Dikic I (2017). Linear ubiquitination of cytosolic Salmonella locally activates NF-ĸB and restricts bacterial proliferation. Nature Microbiology 8, 2:17066.
- Spahn C, Herrmannsdörfer F, Kuner T & Heilemann M (2016). Temporal accumulation analysis provides simplified artifact-free analysis of membrane-protein nanoclusters. Nature Methods 13, 963-964.
- Venkataramani V, Herrmannsdörfer F, Heilemann M & Kuner T (2016). SureSim – Predicting the resolving power of localisation microscopy from ground truth models. Nature Methods 13, 319-21.

Ute Hellmich
- Schirmeister T, Kesselring J, Jung S, Schneider T, Weickert A, Becker J, Lee W, Bamberger D, Wich P, Distler U, Tenzer S, Johé P, Hellmich UA & Engels B (2016) Quantum chemical-based protocol for the rational design of covalent inhibitors.  J. Am. Chem. Soc. 138(27):8332-8335.
- Hellmich UA, Weis BL, Luitikov A, Wurm JP, Christ NA, Hantke K, Kötter P, Entian KD, Schleiff E & Wöhnert J (2013) Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis. Proc. Nat. Acad. Sci. USA 110(38):15253-15258.
- Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardo F, Plata C, Gaudet R, Vicente R & Valverde MA (2013) PIP2-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc. Nat. Acad. Sci. USA 110(23):9553-9558.
- Hellmich, UA, Lyubenova S, Kaltenborn E, Doshi R, van Veen HW, Prisner TF & Glaubitz C (2012) Probing the ATP hydrolysis cycle of the ABC multidrug transporter LmrA by pulsed EPR Spectroscopy. J. Am. Chem. Soc., 134(13):5857-5862.
- Ullrich SJ, Hellmich UA, Ullrich S & Glaubitz C (2011) Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR. Nature Chem Biol. 7(5):263-270. (*contr. equally).

Nadja Hellmann
- Hoven G, Rivas A, Neukirch C, Meyenburg M, Qin Q, Parekh S, Hellmann N & Husmann M  (2017) Repair of a Bacterial Small beta-Barrel Toxin Pore Depends on Channel Width. mBio 8 (1).
Schwiering M, Husmann M & Hellmann N (2017) P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes. Toxins 9 (10).
- Hennig R, Heidrich J, Saur M, Schmüser L, Roeters SJ, Hellmann N et al. (2015) IM30 triggers membrane fusion in cyanobacteria and chloroplasts. Nature communications 6, S. 7018.
- Schwiering M, Brack A, Stork R & Hellmann N (2013) Lipid and phase specificity of alpha-toxin from S. aureus. Biochim Biophys Acta 1828: 1962-1972ES3.
- Schwiering M & Hellmann N (2012) Validation of liposomal lipid composition by thin-layer chromatography. J Liposome Res 22: 279-84.

Gerhard Hummer
- Covino R et al. (2016) A eukaryotic sensor for membrane lipid saturation. Mol Cell 63: 49-59.
- Barends TRM et al. (2015) Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science 350: 445-50.

Franziska Matthäus
- Müller B et al. (2015) Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells, J. Pathol. 237:390-401.
- Schmitt S et al. (2013) Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration, PLoS One 8(9): e75075.

Heinz D. Osiewacz
- Brust D, Daum B, Breunig C, Hamann A, Kühlbrandt W & Osiewacz HD (2010) Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. Aging Cell 9: 761-775.
- Fischer F, Langer JD, Osiewacz HD (2015) Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism. Sci Rep 5: 18375 (doi:10.1038/srep18375).
- Fischer F, Hamann A, Osiewacz HD (2012) Mitochondrial quality control: an integrated network of pathways. Trends Biochem Sci 37: 284-292.
- Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP deficient Podospora anserina strains and extends healthspan. Aging Cell 16:704-715 (doi: 10.1111/acel.12600).
- Knuppertz L, Warnsmann V, Hamann A, Grimm C, Osiewacz HD (2017) Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina. Autophagy 13: 1037-1052 (doi: 10.1080/15548627.2017.1303021).

Enrico Schleiff
- Hsueh YC, Ehmann C, Flinner N, Ladig R & Schleiff E (2017) The plastid outer membrane localized LPTD1 is important for glycerolipid remodelling under phosphate starvation. Plant Cell Environ. 40:1643-1657.
- Jores T, Klinger A, Groß LE, Kawano S, Flinner N, Duchardt-Ferner E, Wöhnert J, Kalbacher H, Endo T, Schleiff E & Rapaport D (2016) Characterization of the targeting signal in mitochondrial β-barrel proteins. Nat Commun. 7:12036.
- Tillmann B, Röth S, Bublak D, Sommer M, Stelzer EHK, Scharf KD & Schleiff E (2015) Hsp90 is involved in the regulation of cytosolic precursor protein abundance in tomato. Mol Plant. 8: 228-241.
- Elkehal R, Becker T, Sommer MS, Königer M, Schleiff E (2012) Specific lipids influence the import capacity of the chloroplast outer envelope precursor protein translocon. Biochim Biophys Acta 1823: 1033–1040.
- Machettira AB, Groß LE, Tillmann B, Weis BLM, Englich G, Sommer MS, Königer M & Schleiff E (2012) Protein induced modulation of chloroplast membrane morphology. Froniers Plant Sci. 2: 118.

Friederike Schmid
- Schmid F (2017) Physical mechanisms of micro- and nanodomain formation in multicomponent lipid membranes, Biochimica et Biophysica Acta 1859, 509.
- Heller P, Weber G, Zhou J, Hobernik D, Bros M, Schmid F & Barz M (2017) The influence of block ionomer microstructure on polyplex properties: Can simulations help to understand differences in transfection efficiency? Small 13, 1603694 (2017).
- Brodbek L & Schmid F (2016) Interplay of curvature-induced micro- and nanodomain structures in multicomponent lipid bilayers, Intnl Adv Eng Sci Appl Math 8, 111.
- Deserno M et al. (2014) Computational studies of biomembrane systems: Theoretical considerations, computer simulation models, and applications, Adv. Polymer Sci. 260, 237.
- Meinhardt S, Vink RLC & Schmid F (2013) Monolayer curvature stabilizes nanoscale raft domains in mixed lipid bilayers, PNAS 110, 4476.

Dirk Schneider
- Hennig R et al. (2015) IM30 triggers membrane fusion in cyanobacteria and chloroplasts, Nature Comm. 6: 7018.
- Zhang X et al. (2016) Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols, Biomaterials 89, 79-88.

Harald Schwalbe
- Herbert C et al. (2016) Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling. Cancer Cell. 30:176-178.
- Zickermann V et al. (2015) Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I. Science. 347:44-9.

Hubert Serve
- Oellerich T et al. (2015) FLT3-ITD and TLR9 use Btk to activate distinct transcriptional programs mediating AML cell survival and proliferation. Blood 125:1936-47. 
- Röllig C et al. (2015) Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial. Lancet Oncol.16(16):1691-9.

Ernst Stelzer
- Chang BJ, Perez Meza VD & Stelzer EHK (2017) csiLSFM combines light-sheet fluorescence microscopy and coherent structured illumination for a lateral resolution below 100 nm. PNAS 114 No 19: 4869-4874. doi: 10.1073/pnas.1609278114.
- von Wangenheim D, Fangerau J, Schmitz A, Smith RS, Leitte H, Stelzer EHK & Maizel A (2016) Rules and self-organizing properties of post-embryonic plant organ cell division patterns. Curr Biol 26: 439-449.
- Stelzer EHK (2015) Light-sheet fluorescence microscopy for quantitative biology. Nat Methods 12: 23-26.
- Vermeer JEM, von Wangenheim D, Barberon M, Lee Y, Stelzer EHK, Maizel A & Geldner N (2014) A spatial accommodation by neighboring cells is required for organ initiation in Arabidopsis. Science 343: 178-183.
- Huisken J, Swoger J, Del Bene F, Wittbrodt J & Stelzer EHK (2004) Optical sectioning deep inside live embryos by selective plane illumination microscopy, Science 305:1007-1009.

Robert Tampé
- Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A & Tampé R (2017) Structure of the human MHC-I peptide-loading complex. Nature 551, 525-8. (highlighted as Front Cover and News & View in Nature and Science).
- Thomas C & Tampé R (2017) Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing. Science 358, 1060-4. (highlighted as Insights/Perspectives in Science).
- Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R & Tampé R (2017) Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Nat Struct Mol Biol 24, 453-460. (highlighted as Front Page and Editorial in Molecular Cell).
- Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Olieric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM & Tampé R (2017) Structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc Natl Acad Sci USA 114, E438-E447.
- Kim JM, Wu, S, Tomasiak T, Mergel C, Winter MN, Stiller S, Robles-Colmanares Y, Stroud RM*, Tampé R*, Craik CS* & Cheng Y* (2015) Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature 517, 396-400. (*corresponding authors).

Ivana von Metzler
- Kaiser MF et al. (2013) The proteasome inhibitor bortezomib stimulates osteoblastic differentiation of human osteoblast precursors via upregulation of vitamin D receptor signalling. Eur J Haematol. 90:263-72.
- Sterz J et al. (2010) BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma. Eur J Haematol. 85:99-107.

Ralph Wieneke
- Kollmannsperger A et al. (2016) Live-cell protein labelling with nanometre precision by cell squeezing. Nature Commun 7, 10372.
- Wieneke R et al. (2015) SLAP: Small labeling pair for single-molecule super-resolution imaging. Angew Chem Int Ed 54, 10216-10219.


Dr. Bernd Märtens

Research Service Center
Goethe-Universität Frankfurt am Main
Max-von-Laue-Str. 9
60348 Frankfurt am Main
Phone: 069/798-49418

Main Research Focus DynaMem


Membrane Dynamics:
Molecular basic principles and theoretical description


Kapitel 15 02,

Förderbuchungskreis 2995
Förderprodukt 11-

Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz (LOEWE)

DynaMem started on
January 1st 2018 with 4 years duration.