cellular homeostasis and surveillance depend on fluxes of information,
molecules, proteins, RNAs and organelles. Understanding the molecular
principles that ensure proper homeostasis and surveillance is fundamental for
the description of the behaviour of an organism and its manipulation by genetic
engineering, breeding or a chemical treatment. Our team aims to understand
central aspects of these processes. We focus on the fundaments of regulating
the life cycle of proteins and the signal transduction systems to maintain the
homeostatic state under changing environmental conditions using plant systems
as a model.
one hand, plant cells operate as eukaryotic cells where fundamental principles
are globally conserved. However, plant cells are more complex than animal cells
due to the existence of the plastids. On the other hand, in conjunction with
the increase of the global population, climate change requires intensive plant
research to ensure the production of food and renewable energy resources.
teamed up in five laboratories. The RiboBio-Lab aims to decipher the regulation of
ribosome production as an example of an essential complex for cellular
homeostasis. The DynaMem-Lab
investigates downstream processes like cellular protein distribution or
organelle positioning in cells as a central cellular function process. To
describe the evolutionary conservation of fundamental processes, the Cyano-Lab
investigates the homeostasis of cyanobacteria as they share common roots with
headed by the group leader Dr. Sotirios Fragkostefanakis describes the
subsequent processes focusing on the plant reaction to altered environmental
conditions like temperature fluctuations.
G-Zero-Lab headed by the group leader Dr. Maik Böhmer targets early responses to
environmental changes by exploring the very early signal transduction and
unified research in these five fields will lead to a global understanding of
the molecular principles that allow cellular homeostasis and surveillance.
of our methods ranges from the investigation of the structure and function of
single proteins over the analysis of energetic processes in isolated membranes,
and evolutionary processes, to genetic analysis of environmentally regulated
processes in plants using different plant model systems.