15
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Biowissenschaften
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Publications


2024

A plant-specific clade of serine/arginine-rich proteins regulates RNA splicing homeostasis and thermotolerance in tomato.
Rosenkranz RRE, Vraggalas S, Keller M, Sankaranarayanan S, McNicoll F, Löchli K, Bublak D, Benhamed M, Crespi M, Berberich T, Bazakos C, Feldbrügge M, Schleiff E, Müller-McNicoll M, Zarnack K, Fragkostefanakis S. Nucleic Acids Res. 2024 Aug 24:gkae730. doi: 10.1093/nar/gkae730. Online ahead of print. PMID: 39180404

hGRAD: A versatile "one-fits-all"system to acutely deplete RNA binding proteins from condensates.

Arnold B, Riegger RJ, Okuda EK, Slišković I, Keller M, Bakisoglu C, McNicoll F, Zarnack K, Müller-McNicoll M. J Cell Biol. 2024 Feb 5;223(2):e202304030. doi: 10.1083/jcb.202304030. Epub 2023 Dec 18. PMID: 3810880

2023

Poison cassette exon splicing of SRSF6 regulates nuclearspeckle dispersal and the response to hypoxia.
de Oliveira Freitas Machado C, Schafranek M, Brüggemann M, Hernández Cañás MC, Keller M, Di Liddo A, Brezski A, Blümel N, Arnold B, Bremm A, Wittig I, Jaé N, McNicoll F, Dimmeler S, Zarnack K, Müller-McNicoll M. Nucleic Acids Res. 2023 Jan 25;51(2):870-890. doi: 10.1093/nar/gkac1225. PMID: 36620874


2022

The G3BP1-UPF1-Associated LongNon-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm.

Kirchhof L, Fouani Y, Knau A, Aslan GS, Heumüller AW, Wittig I, Müller-McNicoll M, Dimmeler S, Jaé N. Noncoding RNA. 2022 Jun 30;8(4):49. doi: 10.3390/ncrna8040049. PMID: 35893232

NMR-derived secondary structure ofthe full-length Ox40 mRNA 3'UTR and its multivalent binding to theimmunoregulatory RBP Roquin.

Tants JN, Becker LM, McNicoll F, Müller-McNicoll M, Schlundt A. Nucleic Acids Res. 2022 Mar 31:gkac212. doi: 10.1093/nar/gkac212. Online ahead of print. PMID: 35357505

Exploring the multifunctionality ofSR proteins.

Slišković I, Eich H, Müller-McNicoll M. Biochem Soc Trans. 2021 Dec 23:BST20210325. doi: 10.1042/BST20210325.


2021

SUMO: Glue or Solvent forPhase-Separated Ribonucleoprotein Complexes and Molecular Condensates?
Keiten-Schmitz J, Röder L, Hornstein E, Müller-McNicoll M, Müller S. Front Mol Biosci. 2021 May 7;8:673038. doi: 10.3389/fmolb.2021.673038.

The SRSF4-GAS5-GlucocorticoidReceptor Axis Regulates Ventricular Hypertrophy.
Larrasa-Alonso J, Villalba-Orero M, Martí-Gómez C, Ortiz-Sánchez P, López-Olañeta MM, Rey-Martín MA, Sánchez-Cabo F, McNicoll F, Müller-McNicoll M, García-Pavía P, Lara-Pezzi E. Circ Res. 2021 Sep 3;129(6):669-683. doi: 10.1161/CIRCRESAHA.120.318577.

SRSF3 and SRSF7 modulate 3'UTRlength through suppression or activation of proximal polyadenylation sites andregulation of CFIm levels
Oliver Daniel Schwich, Nicole Blümel, Mario Keller, Marius Wegener, Samarth Thonta Setty, Melinda Elaine Brunstein, Ina Poser , Igor Ruiz De Los Mozos, Beatrix Suess, Christian Münch, François McNicoll, Kathi Zarnack, Michaela Müller-McNicoll
Genome Biol. 2021 Mar 11;22(1):82.doi: 10.1186/s13059-021-02298-y


2020

A paralog-specific role of COPIvesicles in the neuronal differentiation of mouse pluripotent cells

Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune
Life Sci Alliance. 2020 Jul 14;3(9):e202000714.doi: 10.26508/lsa.202000714

SRSF7 maintains its homeostasisthrough the expression of Split-ORFs and nuclear body assembly.

Vanessa Königs, Camila de Oliveira Freitas Machado, Benjamin Arnold, Nicole Blümel, Anfisa Solovyeva, Sinah Löbbert, Michal Schafranek, Igor Ruiz De Los Mozos, Ilka Wittig, Francois McNicoll, Marcel H. Schulz & Michaela Müller-McNicoll
Nat Struct Mol Biol. 2020 Mar;27(3):260-273. doi: 10.1038/s41594-020-0385-9


2019

View from an mRNP: The Roles of SRProteins in Assembly, Maturation and Turnover.
Marius Wegener & Michaela Müller-McNicoll
Adv Exp Med Biol. 2019;1203:83-112. doi: 10.1007/978-3-030-31434-7_3

A combined computational pipeline todetect circular RNAs in human cancer cells under hypoxic stress.
Antonella Di Liddo, Camila de Oliveira Freitas Machado, Sandra Fischer, Stefanie Ebersberger, Andreas W Heumüller, Julia E Weigand, Michaela Müller-McNicoll, Kathi Zarnack
J Mol Cell Biol. 2019 Sep 27. pii: mjz094. doi: 10.1093/jmcb/mjz094

Long and Repeat-Rich IntronicSequences Favor Circular RNA Formation under Conditions of Reduced SpliceosomeActivity.Mantian Wang, Jingyi Hou, Michaela Müller-McNicoll, Wei Chen, Erin M.Schuman
iScience. 2019 Oct 25;20:237-247. doi: 10.1016/j.isci.2019.08.058

The lncRNA LocusHandsdown Regulates Cardiac Gene Programs and Is Essential for Early MouseDevelopment
Nicole Ritter, Tamer Ali, Nina Kopitchinski, Peggy Schuster, Arica Beisaw, David A. Hendrix, Marcel H. Schulz, Michaela Müller-McNicoll, Stefanie Dimmeler, Phillip Grote
Dev Cell. 2019 Aug 12. doi:10.1016/j.devcel.2019.07.013

Auto-regulatory feedbackby RNA-binding proteins.
Müller-McNicoll M, Rossbach O, Hui J, Medenbach J.
J Mol Cell Biol. 2019 Jun 1. pii: mjz043. doi: 10.1093/jmcb/mjz043

Loss of SRSF3 inCardiomyocytes Leads to Decapping of Contraction Related mRNAs and SevereSystolic Dysfunction.
Ortiz-Sánchez P, Villalba-Orero M, López-Olañeta MM, Larrasa-Alonso J, Sanchez-Cabo F, Martí-Gómez C, Camafeita E, Gomez-Salinero JM, Ramos-Hernández L, Nielsen PJ, Vazquez J, Müller-McNicoll M, Garcia-Pavia P, Lara-Pezzi E.
Circ Res. 2019 May 30. doi: 10.1161/CIRCRESAHA.118.314515

Splicing of long non-coding RNAsprimarily depends on polypyrimidine tract and 5′ splice-site sequences due toweak interactions with SR proteinsKrchnáková Z, Thakur PK, Krausová M, Bieberstein N, Haberman N, Müller-McNicoll M, Stanek D.
Nucleic Acids Research, Volume 47, Issue 2, 25 January 2019, Pages 911–928, https://doi.org/10.1093/nar/gky1147

2018

Characterization ofcis-acting elements that control oscillating alternative splicingGesine Goldammer, Alexander Neumann, Miriam Strauch, Michaela Müller-Mcnicoll, Florian Heyd & Marco Preußner
RNA Biol. 2018 Sep 10:1-12. doi: 10.1080/15476286.2018.1502587. [Epub ahead of print]

A Quantitative Heterokaryon Assay to Measure theNucleocytoplasmic Shuttling of ProteinsFrançois McNicoll, Michaela Müller-McNicoll  
bio-protocol. 2018 Sep 05. doi: DOI:10.21769/BioProtoc.2472

High-Throughput Screens forcis-Acting RNA Sequence Elements That Promote Nuclear Retention.
Zarnack K, Müller-McNicoll M. 
Biochemistry. 2018 May 24. doi: 10.1021/acs.biochem.8b00479. [Epub ahead of print] No abstract available

2017

Nuclear retention of mRNAs - qualitycontrol, gene regulation and disease
Wegener M, Müller-McNicoll M 
Semin Cell Dev Biol. 2017 Nov 1. pii: S1084-9521(17)30442-1. doi: 10.1016/j.semcdb.2017.11.001

Fractionation iCLIP detectspersistent SR protein binding to conserved, retained introns in chromatin,nucleoplasm and cytoplasm 
Brugiolo M, Botti V, Liu N, Müller-McNicoll M, Neugebauer KM
Nucleic Acids Research, PMID: 28977534 DOI: 10.1093/nar/gkx671

TGFβ/SMAD signallingmodulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation
Saul MJ, Groher F, Hegewald AB, Müller-McNicoll M, Marschalek R, Suess B, Steinhilber
Prostaglandins & Other Lipid Mediators, 2017, PMID: 28803964 doi: 10.1016/j.prostaglandins.2017.07.006

RNA secondary structureand nucleotide composition of the conserved hallmark sequence of LeishmaniaSIDER2 retroposons are essential for endonucleolytic cleavage and mRNAdegradation
Hiva Azizi, Tatiany P. Romão, Karen Santos Charret, Prasad K. Padmanabhan, Osvaldo P. de Melo Neto, Michaela Müller-McNicoll, Barbara Papadopoulou
PLOS One, July 13, 2017, doi:https://doi.org/10.1371/journal.pone.0180678

Body Temperature CyclesControl Rhythmic Alternative Splicing in Mammals
Marco Preußner, Gesine Goldammer, Alexander Neumann,&nbspTom Haltenhof, Pia Rautenstrauch, Michaela Müller-McNicoll,Florian Heyd
Molecular Cell , Volume 67 , Issue 3 , 433 - 446.e4, doi: http://dx.doi.org/10.1016/j.molcel.2017.06.006

Cellular differentiation statemodulates the mRNA export activity of SR proteins
Botti V, McNicoll F, Steiner MC, Richter FM, Solovyeva A, Wegener M, Schwich OD, Poser I, Zarnack K, Wittig I, Neugebauer KM, Müller-McNicoll M
J Cell Biol. 2017 Jun 7. pii: jcb.201610051. doi: 10.1083/jcb.201610051

SIDER2 retroposon-mediated mRNAdecay in Leishmania is coupled to translation
Azizi H, Müller-McNicoll M, Papadopoulou B
J. MBio. 2017 Jan 31;8(1). pii: e02288-16. doi: 10.1128/mBio.02288-16.

Differential Binding ofMitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct EditingFates of Mitochondrial mRNA in Trypanosomes
Dixit S, Müller-McNicoll M, David V, Zarnack K, Ule J, Hashimi H, Lukeš
J. MBio. 2017 Jan 31;8(1). pii: e02288-16. doi: 10.1128/mBio.02288-16.

2016

SR proteins are NXF1 adaptors that link alternative RNAprocessing to mRNA export

Michaela Müller-McNicoll, Valentina Botti, Antonio M. de Jesus Domingues, Holger Brandl, Oliver D. Schwich, Michaela C. Steiner, Tomaz Curk, Ina Poser, Kathi Zarnack, and Karla M. Neugebauer
Genes & Dev. 2016. 30: 553-566, doi:10.1101/gad.276477.115


2015

Approaches for StudyingmRNA Decay Mediated by SIDER2 Retroposons in Leishmania 
Barbara Papadopoulou, Michela Müller-McNicoll, Prasad K. Padmanabhan 
DOI: 10.1007/978-1-4939-1438-8_7
In book: Methods in Molecular Biology, Vol. 1201 Parasites Genomic Protocols, Chapter: Approaches for Studying mRNA Decay Mediated by SIDER2 Retroposons in Leishmania, Publisher: Springer, Editors: Christopher Peacock

2014

Good cap/bad cap: how thecap-binding complex determines RNA fate.

Michaela Müller-McNicoll, Neugebauer KM Nat Struct Mol Biol. 2014 Jan;21(1):9-12. doi: 10.1038/nsmb.2751.

2013

How cells get the message: dynamicassembly and function of mRNA-protein complexes.
Müller-McNicoll M, Neugebauer KM.
Nat Rev Genet. 2013 Apr;14(4):275-87. doi: 10.1038/nrg3434. Epub 2013 Mar 12.

2012

The RNA-binding landscapes of two SRproteins reveal unique functions and binding to diverse RNA classes.
Änkö ML, Müller-McNicoll M, Brandl H, Curk T, Gorup C, Henry I, Ule J, Neugebauer KM.
Genome Biol. 2012;13(3):R17. doi: 10.1186/gb-2012-13-3-r17.