23. November 2020
Check out our latest publications on animal-free S9. The pulications cover...
... the optimization of a pre-metabolization procedure for effect-based methods with animal-derived and animal-free metabolisations systems.
Shao, Y., Schiwy, A., Glauch, L., Henneberger, L., König, M., Mühlenbrink, M., Xiao, H., Thalmann, B., Schlichting, R., Hollert, H., Escher, B.I., 2020. Optimization of a pre-metabolization procedure using rat liver S9 and cell-extracted S9 in the Ames fluctuation test. Science of The Total Environment 749, 141468. https://doi.org/10.1016/j.scitotenv.2020.141468
...the variance of animal-derived metabolisations systems within the Ames fluctuations test and the application of a animal-free metablistation system.
Brendt, J., Crawford, S.E., Velki, M., Xiao, H., Thalmann, B., Hollert, H., Schiwy, A., 2020. Is a liver comparable to a liver? A comparison of different rat-derived S9-fractions with a biotechnological animal-free alternative in the Ames fluctuation assay. Science of The Total Environment 143522. https://doi.org/10.1016/j.scitotenv.2020.143522
...and the development and use of a new high-throughput method proposed in our lab for the micronucleus assay that compares animal-free with rat-derived S9 fractions to assess the genotoxicity of substances (Free access: https://authors.elsevier.com/c/1bluuB8ccoMHV).
Brendt, J., Lackmann, C., Heger, S., Velki, M., Crawford, S. E., Xiao, H., Thalmann, B., Schiwy, A., & Hollert, H. (2021). Using a high-throughput method in the micronucleus assay to compare animal-free with rat-derived S9./The Science of the total environment/,/751/, 142269. https://doi.org/10.1016/j.scitotenv.2020.142269
Congrats to Dr. Ying Shao, Dr. Andreas Schiwy and Julia Brendt!