Project duration: 2022–2022
Funding: German Federal Institute for Risk Assessment (BfR)
The chemical risk assessment is conducted via the application of acute fish studies. These studies are animal experiments that should be replaced according to the 3R principle. The Fish Embryo Acute Toxicity (FET) test was developed as an alternative to the acute fish test as it uses less sentient fish larvae. According to scientific reports, the knowledge on xenobiotic transformation capacities in zebrafish embryos, juveniles and adults is fragmentary. Thus, the transferability of toxicity data generated from larvae to adult fish is questionable, as the larvae seem to have lower metabolism capacities.
This project aims to increase the comparability of the FET to the acute fish test by converting the tested substances by external metabolization products (S9-mixes) and then assessing the toxicity of the metabolized substance on the fish larvae. This might increase the forecast power and reliability of the FET and make it more important in risk assessment as an alternative method to the acute fish test.
This project is supported by the German Centre for the Protection of Laboratory Animals (Bf3R) at the German Federal Institute for Risk Assessment (BfR) with the file number 60-0102-01.P608 and will start in January 2022.
Prof. Dr. Dr. h.c. Henner Hollert
Goethe University Frankfurt
Biologicum, Campus Riedberg
60438 Frankfurt am Main, Germany
Phone: +49 (0)69 798 42171
Fax: +49 (0)69 798 42161