NRW – Strategy project BioSC
Funding: SEED FUND 2.0, BioSc — Bioeconmy Science Centre
The NRW strategic project BioSC is supported by:
Co-coordination and Research fellow at the Goethe University, Department Evolutionary Ecology & Environmental Toxicology (E
Co-coordination and Research fellows at the RWTH Aachen:
BioSC webpage: https://www.biosc.de/eng
The project GreenToxiConomy addresses the implementation of a GreenToxicology strategy in developmental processes of novel, and sustainable compounds that are elaborated within the context of the BioEconomy Science Center (BioSC). A GreenToxicology concept aims to evaluate the safety and environmental impacts of new products already during early steps of product development and optimization, thus enabling to focus on less toxic products without delay or financial loss.
The focus of bioeconomy is to replace compounds of modern life with environmentally friendly counterparts that are based on renewable resources. Within this it is of high importance to investigate the ecotoxicological potential for such “green" chemicals, as environmental impacts cannot be excluded in principle. This project aims to develop a substance-specific and exposure-based proof-of-concept strategy for the two product categories biosurfactants (rhamnolipdies, mannosylerythritol lipids, ustilagic acids) and microgel containers as well as anchoring peptides for the latter. Biosurfactants have a broad range of potential applications including in detergents, remediation or pharmacy. Microgel containers are planned as novel pesticide release systems for plant protection significantly reducing the application amount. Against this background, both substance classes have a high potential to end up in the aquatic and terrestrial environment.
The planned project approach includes as first step to develop and establish ecotoxicological test batteries for the individual product categories considering physical-chemical properties as well as the fields of application. For this literature data and in silico prediction tools will be applied to obtain initial information on toxic potencies of the substances and prioritize biological endpoints of further testing. Afterwards bioassays will be adapted to the specific compounds requirements before the biosurfactants and microgels will be finally investigated to evaluate their ecotoxicological potential.
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Prof. Dr. rer. nat. Henner Hollert
Goethe University Frankfurt
Biologicum, Campus Riedberg
60438 Frankfurt am Main, Germany
Phone: +49 (0)69 798 42171
Fax: +49 (0)69 798 42161